Ethyl 4-oxocyclohexanecarboxylate → HCID 54756043, compound

HRID 2089224Notes

Reaction equation

HRID 2089224 reaction equation
OC(C(F)(F)F)=O.[C:8]([NH:12][C:13]([N:15]1[C:23]2[C:18](=[CH:19][C:20]([C:24]([F:27])([F:26])[F:25])=[CH:21][CH:22]=2)[C:17]([NH:28][CH2:29][C:30](=[O:36])[NH:31][CH:32]2[CH2:35][NH:34][CH2:33]2)=[N:16]1)=[O:14])([CH3:11])([CH3:10])[CH3:9].[CH2:37]([O:39][C:40]([CH:42]1[CH2:47][CH2:46][C:45](=O)[CH2:44][CH2:43]1)=[O:41])[CH3:38]>>[CH2:37]([O:39][C:40]([CH:42]1[CH2:47][CH2:46][CH:45]([N:34]2[CH2:33][CH:32]([NH:31][C:30](=[O:36])[CH2:29][NH:28][C:17]3[C:18]4[C:23](=[CH:22][CH:21]=[C:20]([C:24]([F:26])([F:25])[F:27])[CH:19]=4)[N:15]([C:13](=[O:14])[NH:12][C:8]([CH3:11])([CH3:9])[CH3:10])[N:16]=3)[CH2:35]2)[CH2:44][CH2:43]1)=[O:41])[CH3:38]

Participants

3

Reactant 2

HCID 317638Ethyl 4-oxocyclohexanecarboxylateHCID 1317305553-[(azetidin-3-ylcarbamoylmethyl)-amino]-5-trifluoromethyl-indazole-1-carboxylic acid tert-butyl amide TFA salt

Product 1

HCID 54756043HCID 54756043, compound

Procedure

The title compound was prepared as a white solid from reaction of 3-[(azetidin-3-ylcarbamoylmethyl)-amino]-5-trifluoromethyl-indazole-1-carboxylic acid tert-butyl amide TFA salt (as prepared in Example 81, Step D) and 4-oxo-cyclohexanecarboxylic acid ethyl ester using the procedure described in Step E of Example 1.

Sources & evidence

ORD record
ord-37936246ed5c42f28830d05d89be80c7
Source dataset
uspto-grants-2013_05
Patent number
US08436023B2

Reaction notes

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