Ethyl 4-oxocyclohexanecarboxylate → 4-{3-[2-(1-Benzyl-5-trifluoromethyl-1H-indazol-3-ylamino)-acetylamino]-azetidin-1-yl}-cyclohexane carboxylic acid ethyl ester
반응식
[NH:1]1[CH2:4][CH:3]([NH:5][C:6](=[O:29])[CH2:7][NH:8][C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([C:18]([F:21])([F:20])[F:19])[CH:16]=3)[N:11]([CH2:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[N:10]=2)[CH2:2]1.[CH2:30]([O:32][C:33]([CH:35]1[CH2:40][CH2:39][C:38](=O)[CH2:37][CH2:36]1)=[O:34])[CH3:31]>>[CH2:30]([O:32][C:33]([CH:35]1[CH2:40][CH2:39][CH:38]([N:1]2[CH2:2][CH:3]([NH:5][C:6](=[O:29])[CH2:7][NH:8][C:9]3[C:17]4[C:12](=[CH:13][CH:14]=[C:15]([C:18]([F:20])([F:19])[F:21])[CH:16]=4)[N:11]([CH2:22][C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)[N:10]=3)[CH2:4]2)[CH2:37][CH2:36]1)=[O:34])[CH3:31]참가 물질
3
실험 절차
The title compound was prepared as a white solid from reaction of N-azetidin-3-yl-2-(1-benzyl-5-trifluoromethyl-1H-indazol-3-ylamino)-acetamide and 4-oxo-cyclohexanecarboxylic acid ethyl ester using the procedure described in Step E of Example 1.
출처 및 근거
- ORD 기록
- ord-151d8a12e30342c485a0a2cc76f66d8e
- 출처 데이터셋
- uspto-grants-2013_05
- 특허 번호
- US08436023B2
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