4-Isopropylcyclohexanone → 2-(1-Benzyl-5-trifluoromethyl-1H-indazol-3-ylamino)-N-[1-(4-isopropyl-cyclohexyl)-azetidin-3-yl]-acetamide
Reaktionsgleichung
[NH:1]1[CH2:4][CH:3]([NH:5][C:6](=[O:29])[CH2:7][NH:8][C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([C:18]([F:21])([F:20])[F:19])[CH:16]=3)[N:11]([CH2:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[N:10]=2)[CH2:2]1.[CH:30]([CH:33]1[CH2:38][CH2:37][C:36](=O)[CH2:35][CH2:34]1)([CH3:32])[CH3:31]>>[CH2:22]([N:11]1[C:12]2[C:17](=[CH:16][C:15]([C:18]([F:20])([F:19])[F:21])=[CH:14][CH:13]=2)[C:9]([NH:8][CH2:7][C:6]([NH:5][CH:3]2[CH2:2][N:1]([CH:36]3[CH2:37][CH2:38][CH:33]([CH:30]([CH3:32])[CH3:31])[CH2:34][CH2:35]3)[CH2:4]2)=[O:29])=[N:10]1)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1Komponenten
3
Versuchsvorschrift
The title compound was prepared as a white solid from reaction of N-azetidin-3-yl-2-(1-benzyl-5-trifluoromethyl-1H-indazol-3-ylamino)-acetamide and 4-isopropyl-cyclohexanone using the procedure described in Step E of Example 1.
Quellen und Nachweise
- ORD-Eintrag
- ord-6b3ab910bf7a4df6a39e4410bcf0d604
- Quelldatensatz
- uspto-grants-2013_05
- Patentnummer
- US08436023B2
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