Methanesulfonyl chloride → 2-(1-Methanesulfonyl-5-trifluoromethyl-1H-indazol-3-yl)-isoindole-1,3-dione

関与物質

反応手順

2-(5-Trifluoromethyl-1H-indazol-3-yl)-isoindole-1,3-dione (350 mg, 1.06 mmol), TEA (0.3 mL, 2.12 mmol) in DCM (5 mL) was treated with MsCl (182 mg, 1.59 mmol) at 0° C. for 2 hours. The solvent was removed and the residue was purified by silica gel column chromatography using hexanes:ethyl acetate 1:1 to give the title compound as white solid (305 mg, 69%).

情報源と証拠