Ethyl 4-oxocyclohexanecarboxylate → 4-{3-[2-(1-Methanesulfonyl-5-trifluoromethyl-1H-indazol-3-ylamino)-acetylamino]-azetidin-1-yl}-cyclohexane carboxylic acid ethyl ester

HRID 2089236Notes

Reaction equation

HRID 2089236 reaction equation
OC(C(F)(F)F)=O.[NH:8]1[CH2:11][CH:10]([NH:12][C:13](=[O:33])[CH2:14][NH:15][C:16]2[C:24]3[C:19](=[CH:20][CH:21]=[C:22]([C:25]([F:28])([F:27])[F:26])[CH:23]=3)[N:18]([S:29]([CH3:32])(=[O:31])=[O:30])[N:17]=2)[CH2:9]1.[CH2:34]([O:36][C:37]([CH:39]1[CH2:44][CH2:43][C:42](=O)[CH2:41][CH2:40]1)=[O:38])[CH3:35]>>[CH2:34]([O:36][C:37]([CH:39]1[CH2:44][CH2:43][CH:42]([N:8]2[CH2:11][CH:10]([NH:12][C:13](=[O:33])[CH2:14][NH:15][C:16]3[C:24]4[C:19](=[CH:20][CH:21]=[C:22]([C:25]([F:27])([F:28])[F:26])[CH:23]=4)[N:18]([S:29]([CH3:32])(=[O:31])=[O:30])[N:17]=3)[CH2:9]2)[CH2:41][CH2:40]1)=[O:38])[CH3:35]

Participants

3

Reactant 2

HCID 317638Ethyl 4-oxocyclohexanecarboxylateHCID 86660185N-azetidin-3-yl-2-(1-methanesulfonyl-5-trifluoromethyl-1H-indazol-3-ylamino)-acetamide TFA salt

Product 1

HCID 566785064-{3-[2-(1-Methanesulfonyl-5-trifluoromethyl-1H-indazol-3-ylamino)-acetylamino]-azetidin-1-yl}-cyclohexane carboxylic acid ethyl ester

Procedure

The title compound was prepared as a white solid from reaction of N-azetidin-3-yl-2-(1-methanesulfonyl-5-trifluoromethyl-1H-indazol-3-ylamino)-acetamide TFA salt and 4-oxo-cyclohexanecarboxylic acid ethyl ester using the procedure described in Step E of Example 1.

Sources & evidence

ORD record
ord-25eb1ac153c1431a84293267defa487d
Source dataset
uspto-grants-2013_05
Patent number
US08436023B2

Reaction notes

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