Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl Acetate → 2-Fluoro-5-(2,2,2-trifluoro-ethoxy)-benzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1,1,1-Trifluoro-2-iodoethane | HCID 67709 | — |
| 반응물 | 2-Fluoro-5-hydroxybenzonitrile | HCID 22612410 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 2-Fluoro-5-(2,2,2-trifluoro-ethoxy)-benzonitrile | HCID 67478771 | 48% |
반응 단계
To a solution of 2-fluoro-5-hydroxy-benzonitrile (Alfa Aesar, 137 mg, 1.0 mmol) was added 2-iodo-1,1,1,-trifluoroethane (117 L, 1.2 mmol) and potassium carbonate (165 mg, 1.2 mmol) in DMF (20 mL) and stirred at RT for 24 hours. The reaction was dissolved into EtOAc and washed with water three times and the combined organic layers were dried over anhydrous Na2SO4 and concentrated. The residue was purified by silica gel column chromatography using hexanes:ethyl acetate 5:1 to give the tile compound as white solid (105 mg, 48%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08436023B2 |
| 출처 데이터셋 | uspto-grants-2013_05 |
| ORD ID | ord-c4c55e7bff9c4503b75ee8b44229ae9f |
| 출처 메모 | uspto-grants-2013_05 |