HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 2-Chloro-5-(trifluoromethyl)pyridine-3-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 2-Chloro-5-(trifluoromethyl)nicotinic acid | HCID 12140227 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Chloro-5-(trifluoromethyl)pyridine-3-carbonyl chloride | HCID 37863460 | — |
Reaction Steps
To a suspension of 2-chloro-5-(trifluoromethyl)nicotinic acid (1.147 g, 4.83 mmol) in DCM (20 mL) was added oxalyl chloride (630 L, 7.35 mmol) dropwise with stirring. A single drop of DMF was added and the reaction mixture was stirred 40° C. for 1 hour. Concentration of the reaction mixture in vacuo resulted in the title compound as a brown oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08436023B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-37f91c9a324049e7929dcaded6fe7233 |
| Source note | uspto-grants-2013_05 |