1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 67479092, compound

Participants

Reaction Steps

Into a 50-mL round-bottom flask, was placed 2-((1-methyl-5-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)amino)acetic acid (as prepared in the previous step, 134 mg, 0.49 mmol) followed by DCM (20 mL), tert-butyl 3-aminoazetidine-1-carboxylate (104 mg, 0.60 mmol), EDCI (104 mg, 0.54 mmol) and HOBt (75 mg, 0.49 mmol). The reaction mixture was stirred overnight at room temperature and then concentrated in vacuo. The resulting residue was purified by flash chromatography (silica gel, 0-20% MeOH/ethyl acetate) to afford the title compound in sufficient purity to conduct the next step.

Provenance & Evidence