Methyl iodide → HCID 67092529, compound

Participants

Reaction Steps

5-[1-(4-cyanophenyl)-1H-pyrazol-5-yl]-6-methyl-2-oxo-N-(3-pyrrolidin-1-ylpropyl)-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide was reacted with iodomethane using an analogous method to that described in Step 2 of Example 4 to afford the title compound (154 mg, 68%) as a white solid; 1H NMR (500 MHz, DMSO) δ 1.82 (3H, s), 1.93 (2H, td), 2.10-2.01 (4H, m), 2.94 (3H, s), 3.31-3.27 (4H, m), 3.49-3.34 (4H, m), 6.72 (1H, d), 7.67 (2H, d), 7.71 (1H, d), 7.88-7.83 (2H, m), 7.97-7.91 (4H, m), 8.03 (1H, s), 9.40 (1H, t); APCI-MSm/z: 589[M+]

Provenance & Evidence