Methyl iodide → HCID 67092464, compound

Participants

Reaction Steps

6-[1-(4-Cyanophenyl)-1H-pyrazol-5-yl]-N-[3-(dimethylamino)propyl]-5-methyl-3-oxo-4-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazine-2-carboxamide was reacted with iodomethane using an analogous method to that described in Step 2 of Example 4 to afford the title compound (26 mg, 24%) as a white solid; 1H NMR (500 MHz, DMSO) δ 1.91-1.83 (2H, m), 1.93 (3H, s), 3.01 (9H, s), 3.30-3.23 (4H, m), 6.77 (1H, d), 7.69 (2H, d), 7.78 (1H, d), 7.92-7.87 (3H, m), 7.99-7.93 (3H, m), 8.93 (1H, t); APCI-MSm/z: 564 [M+]

Provenance & Evidence