Dinitrofluorobenzene → HCID 44254850, compound

Participants

Reaction Steps

To a solution of 4-aminobenzylamine (25.5 mL, 225 mmol) and powdered NaHCO3 (94.5 g, 1125 mmol) in anhydrous DMF (300 mL) was added 2,4-dinitrofluorbenzene (1) (18.8 mL, 150 mmol) dropwise at room temperature. After 2 hours, the solution was slowly diluted with water (1000 mL) to precipitate the product, which was collected on a fritted funnel while rinsing with water until the eluent was colorless. The solid was further dried under high vacuum to afford 43.0 g as a bright orange solid in 99% yield.

Provenance & Evidence