HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,6-Dihydro-2H-pyran-4-boronic acid pinacol ester → HCID 58464781, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,6-Dihydro-2H-pyran-4-boronic acid pinacol ester | HCID 11218053 | — |
| Reactant | 5-chloro-1-methyl-4-nitro-1H-pyrazole | HCID 12344836 | — |
| Product | HCID 58464781 | HCID 58464781 | 65% |
Reaction Steps
Following Example 231, reaction of 5-chloro-1-methyl-4-nitro-1H-pyrazole and 3,6-dihydro-2H-pyran-4-boronic acid pinacol ester gave 5-(3,6-dihydro-2H-pyran-4-yl)-1-methyl-4-nitro-1H-pyrazole (167 mg, 65%). 1H NMR (400 MHz, CDCl3) δ 8.09 (s, 1H), 5.99-5.94 (m, 1H), 4.37 (q, J=2.8 Hz, 2H), 3.99 (t, J=5.3 Hz, 2H), 3.84 (s, 3H), 2.40-2.35 (m, 2H)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08436001B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-9d0c22e0179c48d890ef5c2c9581a185 |
| Source note | uspto-grants-2013_05 |