4,4-Difluoropiperidine hydrochloride → HCID 58465091, compound

HRID 2089366Notes

Reaction equation

HRID 2089366 reaction equation
Cl[C:2]1[N:6]([CH3:7])[N:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9].Cl.[F:12][C:13]1([F:19])[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1>>[F:12][C:13]1([F:19])[CH2:18][CH2:17][N:16]([C:2]2[N:6]([CH3:7])[N:5]=[CH:4][C:3]=2[N+:8]([O-:10])=[O:9])[CH2:15][CH2:14]1

Participants

3

Reactant 2

HCID 27583514,4-Difluoropiperidine hydrochlorideHCID 123448365-chloro-1-methyl-4-nitro-1H-pyrazole

Product 1

HCID 58465091HCID 58465091, compoundYield 97%

Procedure

Reaction of 5-chloro-1-methyl-4-nitro-1H-pyrazole and 4,4 di-fluoropiperidine hydrochloride gave 4,4-difluoro-1-(1-methyl-4-nitro-1H-pyrazol-5-yl)piperidine as a white solid (289 mg, 97%). 1H NMR (400 MHz, CDCl3) δ 8.03 (s, 1H), 3.79 (s, 3H), 3.36-3.31 (m, 4H), 2.22-2.09 (m, 4H)

Sources & evidence

ORD record
ord-45d8df8823614da6b7542cc48e9c0522
Source dataset
uspto-grants-2013_05
Patent number
US08436001B2

Reaction notes

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