3-Fluoropyrrolidine → HCID 58464854, compound

HRID 2089368Notes

Reaction equation

HRID 2089368 reaction equation
Cl[C:2]1[N:6]([CH3:7])[N:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9].[F:11][C@@H:12]1[CH2:16][CH2:15][NH:14][CH2:13]1>>[F:11][C@@H:12]1[CH2:16][CH2:15][N:14]([C:2]2[N:6]([CH3:7])[N:5]=[CH:4][C:3]=2[N+:8]([O-:10])=[O:9])[CH2:13]1

Participants

3

Reactant 2

HCID 27591633-FluoropyrrolidineHCID 123448365-chloro-1-methyl-4-nitro-1H-pyrazole

Product 1

HCID 58464854HCID 58464854, compoundYield 58%

Procedure

Reaction of 5-chloro-1-methyl-4-nitro-1H-pyrazole and (R)-3-fluoropyrrolidine gave (R)-5-(3-fluoropyrrolidin-1-yl)-1-methyl-4-nitro-1H-pyrazole as a yellow solid (153 mg, 58%). 1H NMR (400 MHz, CDCl3) δ 8.06 (s, 1H), 5.48-5.31 (m, 1H), 3.79 (s, 3H), 3.73-3.57 (m, 2H), 3.48-3.37 (m, 2H), 2.46-2.27 (m, 2H)

Sources & evidence

ORD record
ord-7b29881a3287435f884ed90cace7f2ec
Source dataset
uspto-grants-2013_05
Patent number
US08436001B2

Reaction notes

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