Cyclohexanol → HCID 58465052, compound

HRID 2089380Notes

Reaction equation

HRID 2089380 reaction equation
Cl[C:2]1[N:6]([CH3:7])[N:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9].[CH:11]1([OH:17])[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1>>[CH:11]1([O:17][C:2]2[N:6]([CH3:7])[N:5]=[CH:4][C:3]=2[N+:8]([O-:10])=[O:9])[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1

Participants

3

Reactant 2

HCID 7966CyclohexanolHCID 123448365-chloro-1-methyl-4-nitro-1H-pyrazole

Product 1

HCID 58465052HCID 58465052, compoundYield 47%

Procedure

Following the procedure for Example 230 reaction of 5-chloro-1-methyl-4-nitro-1H-pyrazole and cyclohexanol gave 5-(cyclohexyloxy)-1-methyl-4-nitro-1H-pyrazole as off-white solid (132 mg, 47%). 1H NMR (400 MHz, CDCl3) δ 7.99 (s, 1H), 4.76-4.67 (m, 1H), 3.70 (s, 3H), 2.10-2.02 (m, 2H), 1.85-1.78 (m, 2H), 1.64-1.52 (m, 2H), 1.43-1.22 (m, 3H), 0.96-0.81 (m, 1H)

Sources & evidence

ORD record
ord-d0193ed71df444418c930aea5386403e
Source dataset
uspto-grants-2013_05
Patent number
US08436001B2

Reaction notes

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