HRID2089419

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID58182203

5-[[(1,1-Dimethylethoxy)carbonyl]amino]-4-thiazolecarboxylic acid

C9H12N2O4S

结构：Cn1ncc(N)c1N1CCC[C@@H](NC(=O)OCc2ccccc2)CC1

HCID58465005

未命名化合物

结构：CC(C)(C)OC(=O)Nc1sc(-c2cc(Br)ccc2F)nc1C(=O)O

HCID67437597

未命名化合物

PRODUCTS

生成物

结构：Cn1ncc(NC(=O)c2nc(-c3cc(Br)ccc3F)sc2N)c1N1CCC[C@@H](N)CC1

HCID58465081

未命名化合物

PROCEDURE

实验过程

Following procedures from Examples 140, (R)-benzyl 1-(4-amino-1-methyl-1H-pyrazol-5-yl)azepan-4-ylcarbamate from Example 16 and the product of Example 27, 245-bromo-2-fluorophenyl)-5-(tert-butoxycarbonylamino)thiazole-4-carboxylic acid, were converted to 308. 1H NMR (400 MHz, DMSO) δ 9.05 (s, 1H), 8.45 (dd, J=6.7, 2.5 Hz, 1H), 7.66-7.55 (m, 1H), 7.48 (s, 2H), 7.43 (s, 1H), 7.36 (dd, J=11.2, 8.9 Hz, 1H), 3.65 (s, 4H), 3.21-2.93 (m, 7H), 1.84 (dd, J=8.2, 3.6 Hz, 3H), 1.72-1.39 (m, 3H). MS (ESI) m/z: 508.1/510.1 [M+H+].