1-(2-Hydroxyethyl)piperazine → HCID 58465076, compound

HRID 2089426Notes

Reaction equation

HRID 2089426 reaction equation
Cl[C:2]1[N:6]([CH3:7])[N:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9].[N:11]1([CH2:17][CH2:18][OH:19])[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1>>[CH3:7][N:6]1[C:2]([N:14]2[CH2:15][CH2:16][N:11]([CH2:17][CH2:18][OH:19])[CH2:12][CH2:13]2)=[C:3]([N+:8]([O-:10])=[O:9])[CH:4]=[N:5]1

Participants

3

Reactant 2

HCID 76771-(2-Hydroxyethyl)piperazineHCID 123448365-chloro-1-methyl-4-nitro-1H-pyrazole

Product 1

HCID 58465076HCID 58465076, compoundYield 95%

Procedure

Reaction of 5-chloro-1-methyl-4-nitro-1H-pyrazole and 2-(piperazin-1-yl)ethanol gave 2-(4-(1-methyl-4-nitro-1H-pyrazol-5-yl)piperazin-1-yl)ethanol as a cream solid (0.30 g, 95%). 1H NMR (400 MHz, CDCl3) δ 8.03 (s, 1H), 3.78 (s, 3H), 3.67 (t, J=5.3 Hz, 2H), 3.26 (t, J=4.6 Hz, 4H), 2.72-2.62 (m, 6H). OH not seen

Sources & evidence

ORD record
ord-2862f62e34db4793aada29176f6a18c6
Source dataset
uspto-grants-2013_05
Patent number
US08436001B2

Reaction notes

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