HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2,2-difluoroethyl)-4-nitro-1H-pyrazole → 1-(2,2-difluoroethyl)-1H-pyrazol-4-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2,2-difluoroethyl)-4-nitro-1H-pyrazole | HCID 19614647 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-(2,2-difluoroethyl)-1H-pyrazol-4-amine | HCID 19576663 | 93.5% |
Reaction Steps
1-(2,2-difluoroethyl)-4-nitro-pyrazole (235 mg, 1.33 mmol) was dissolved in methanol (50 mL) and hydrogenated on H-Cube at 50° C. and 40 bar pressure to give 1-(2,2-difluoroethyl)pyrazol-4-amine (183 mg, 93%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08436001B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-aa4d598ac08340dca1b1688e3d782f19 |
| Source note | uspto-grants-2013_05 |