Isopropanol → HCID 178459416, compound

Participants

Reaction Steps

To imidazole-4-carboxylic acid (CAS#1072-84-0, 3.0 g, 26.7 mmol) in propan-2-ol (60 mL) is added thionyl chloride (15.9 g, 13.4 mmol) and the solution is refluxed overnight. The volatiles are removed in vacuo and the residue is partitioned between ethyl acetate and 4M aqueous sodium hydroxide. The organic layer is dried-over Na2SO4, filtered and concentrated to afford imidazole-4-carboxylic acid isopropyl ester; MS: (ESI) m/z 155.0 (M+H)+.

Provenance & Evidence