Acetic Anhydride → HCID 67547382, compound

Participants

Reaction Steps

To a solution of 7-methoxy-2,2-dimethyl-3,4-dihydro-2H-naphthalen-1-ol (1.40 g, 6.52 mmol) and DMAP (0.16 g, 1.30 mmol) in dichloromethane (30 mL) is added triethylamine (1.99 g, 19.55 mmol) and acetic anhydride (1.68 g, 16.29 mmol). After 45 min, the mixture is diluted with ethyl acetate and washed successively with 1M aqueous sodium bisulfate, saturated aqueous sodium bicarbonate, and brine. The organic phase is dried over magnesium sulfate, filtered, and concentrated to give acetic acid 7-methoxy-2,2-dimethyl-1,2,3,4-tetrahydro-naphthalen-1-yl ester, which is used in the next step without further purification.

Provenance & Evidence