反应详情

温度

-15 °C

N-(4-phenoxy-phenyl)-acetamide (1.00 g, 4.03 mmol) prepared in Step A was dissolved in fuming nitric acid (2 mL), and the mixture was stirred for 2 h at −15° C. After completion of the reaction, the reaction mixture was poured into 100 mL of ice water, which was then extracted with ethyl acetate. The extracted organic solution was dried over anhydrous magnesium sulfate, the solvent was removed under reduced pressure, and the residue was purified by column chromatography to give the title compound (0.67 g, 2.33 mmol).

1. customAfter completion of the reaction
2. extractionwas then extracted with ethyl acetate
3. dry with materialThe extracted organic solution was dried over anhydrous magnesium sulfate
4. customthe solvent was removed under reduced pressure
5. customthe residue was purified by column chromatography