Cyclopentanone → 2-[7-(cyclopentylamino)-2-phenyl-1H-indol-5-yl]ethanol

HRID 2089588Notes

Reaction equation

HRID 2089588 reaction equation
C([O:3][C:4](=O)[CH2:5][C:6]1[CH:7]=[C:8]2[C:12](=[C:13]([NH:15][CH:16]3[CH2:20][CH2:19][CH2:18][CH2:17]3)[CH:14]=1)[NH:11][C:10]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[CH:9]2)C.C1(=O)CCCC1>>[CH:16]1([NH:15][C:13]2[CH:14]=[C:6]([CH2:5][CH2:4][OH:3])[CH:7]=[C:8]3[C:12]=2[NH:11][C:10]([C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)=[CH:9]3)[CH2:17][CH2:18][CH2:19][CH2:20]1

Participants

3

Reactant 2

HCID 8452CyclopentanoneHCID 25214181HCID 25214181, compound

Product 1

HCID 252141822-[7-(cyclopentylamino)-2-phenyl-1H-indol-5-yl]ethanolYield 80%

Procedure

2-[7-(Cyclopentyl)amino-2-phenyl-1H-indol-5-yl]acetic acid ethyl ester prepared in Example 31 and cyclopentanone were reacted according to the same procedure as Example 29 to give the title compound (257 mg, Yield 80%).

Sources & evidence

ORD record
ord-d1eb6655f5664757bb5d8cc8676baaa2
Source dataset
uspto-grants-2013_05
Patent number
US08436038B2

Reaction notes

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