1,1-Dioxo-tetrahydro-thiopyran-4-one → HCID 25214185, compound

HRID 2089590Notes

Reaction equation

HRID 2089590 reaction equation
C([O:3][C:4](=[O:22])[CH2:5][C:6]1[CH:7]=[C:8]2[C:12](=[C:13]([NH2:15])[CH:14]=1)[NH:11][C:10]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[CH:9]2)C.[O:23]=[S:24]1(=[O:31])[CH2:29][CH2:28][C:27](=O)[CH2:26][CH2:25]1>>[C:16]1([C:10]2[NH:11][C:12]3[C:8]([CH:9]=2)=[CH:7][C:6]([CH2:5][C:4]([OH:3])=[O:22])=[CH:14][C:13]=3[NH:15][CH:27]2[CH2:28][CH2:29][S:24](=[O:31])(=[O:23])[CH2:25][CH2:26]2)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 2622301,1-Dioxo-tetrahydro-thiopyran-4-oneHCID 68470222HCID 68470222, compound

Product 1

HCID 25214185HCID 25214185, compound

Procedure

2-(2-Phenyl-7-amino-1H-indol-5-yl)acetic acid ethyl ester prepared as an intermediate in the process of Example 31 and 1,1-dioxo-tetrahydro-thiopyran-4-one were reacted according to the same procedures as Step B of Example 1 and Example 30 to give the title compound.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-3652ddd7c97f43d09cfd42294bf0e861
Source dataset
uspto-grants-2013_05
Patent number
US08436038B2

Reaction notes

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