HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydro-4H-pyran-4-one → (Tetrahydropyran-4-yl)-[2-phenyl-5-(2-oxo-piperazin-4-yl)methyl-1H-indol-7-yl]amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydro-4H-pyran-4-one | HCID 121599 | — |
| Reactant | Piperazin-2-one | HCID 231360 | — |
| Reactant | 5-Hydroxymethyl-2-phenyl-7-nitro-1H-indole | HCID 68476377 | — |
| Product | (Tetrahydropyran-4-yl)-[2-phenyl-5-(2-oxo-piperazin-4-yl)methyl-1H-indol-7-yl]amine | HCID 68477863 | — |
Reaction Steps
5-Hydroxymethyl-2-phenyl-7-nitro-1H-indole prepared in Step A of Example 29, 2-oxopiperazine and 4-oxo-tetrahydropyran were sequentially reacted according to the same procedure as Example 36 to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08436038B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-cb95c21ad84243218ec7594fbad2dfbd |
| Source note | uspto-grants-2013_05 |