Methanesulfonyl chloride → HCID 25216169, compound

HRID 2089601Notes

Reaction equation

[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([NH:11][CH:12]3[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]3)[CH:10]=1)[NH:7][C:6]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[CH:5]2.[CH3:24][S:25](Cl)(=[O:27])=[O:26]>>[CH3:24][S:25]([N:15]1[CH2:14][CH2:13][CH:12]([NH:11][C:9]2[CH:10]=[C:2]([CH3:1])[CH:3]=[C:4]3[C:8]=2[NH:7][C:6]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[CH:5]3)[CH2:17][CH2:16]1)(=[O:27])=[O:26]

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 25216168HCID 25216168, compound

Product 1

HCID 25216169HCID 25216169, compound

Procedure

(5-Methyl-2-phenyl-1H-indol-7-yl)-piperidin-4-yl-amine prepared in Example 90 and methanesulfonylchloride were reacted according to the same procedure as Example 22 to give the title compound.

Sources & evidence

ORD record: ord-fa9671468c30421b96ececbb2d3d677b
Source dataset: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08436038B2

Reaction notes

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