Methyl 4-oxocyclohexanecarboxylate → HCID 68476533, compound

HRID 2089608Notes

Reaction equation

HRID 2089608 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([NH2:11])[CH:10]=1)[NH:7][C:6]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[CH:5]2.C[O:19][C:20]([CH:22]1[CH2:27][CH2:26][C:25](=O)[CH2:24][CH2:23]1)=[O:21]>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([NH:11][CH:25]3[CH2:26][CH2:27][CH:22]([C:20]([OH:21])=[O:19])[CH2:23][CH2:24]3)[CH:10]=1)[NH:7][C:6]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[CH:5]2

Participants

3

Reactant 2

HCID 226643Methyl 4-oxocyclohexanecarboxylateHCID 68478397HCID 68478397, compound

Product 1

HCID 68476533HCID 68476533, compound

Procedure

7-Amino-5-chloro-2-phenyl-1H-indole prepared in Example 3 and 4-oxo-cyclohexane-1-carboxylic acid methyl ester were reacted according to the same procedures as Step B of Example 1 and Example 30 sequentially to give the title compound.

Sources & evidence

ORD record
ord-57e1afa2d1674cfbbf299820a35c98b1
Source dataset
uspto-grants-2013_05
Patent number
US08436038B2

Reaction notes

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