Thiomorpholine 1,1-dioxide → HCID 68475957, compound

HRID 2089620Notes

Reaction equation

HRID 2089620 reaction equation
CO[C:3](=O)[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]2[NH:12][C:13]3[C:18]([CH:19]=2)=[CH:17][C:16]([Cl:20])=[CH:15][C:14]=3[NH:21][CH:22]2[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)[CH:6]=1.[O:29]=[S:30]1(=[O:36])[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]1>>[Cl:20][C:16]1[CH:17]=[C:18]2[C:13](=[C:14]([NH:21][CH:22]3[CH2:27][CH2:26][O:25][CH2:24][CH2:23]3)[CH:15]=1)[NH:12][C:11]([C:7]1[CH:8]=[CH:9][CH:10]=[C:5]([CH2:4][CH2:3][N:33]3[CH2:34][CH2:35][S:30](=[O:36])(=[O:29])[CH2:31][CH2:32]3)[CH:6]=1)=[CH:19]2

Participants

3

Reactant 2

HCID 6484228Thiomorpholine 1,1-dioxideHCID 684777332-[3-(7-Tetrahydropyran-4-ylamino-5-chloro-1H-indol-2-yl)-phenyl]-acetic acid methyl ester

Product 1

HCID 68475957HCID 68475957, compound

Procedure

2-[3-(7-Tetrahydropyran-4-ylamino-5-chloro-1H-indol-2-yl)-phenyl]-acetic acid methyl ester prepared in Example 132 and 1,1-dioxo-thiomorpholine were reacted according to the same procedures as Example 32 and Steps A and B of Example 36 sequentially to give the title compound.

Sources & evidence

ORD record
ord-6f368b0b85254dcfa370679790addbcf
Source dataset
uspto-grants-2013_05
Patent number
US08436038B2

Reaction notes

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