Toluene → HCID 86677400, compound

Participants

Reaction Steps

To a mixture of 3-methoxymethoxy-2,2-dimethylpropionic acid 5-{(R)-[4-(amino[benzoylimino]methyl)phenylamino]-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxymethyl ester (Example 1f, 300 mg), TBME (4 mL), toluene (4 mL), and isopropyl alcohol (2 mL), 4 N hydrogen chloride-ethyl acetate solution (0.098 mL) was slowly added, and the resulting mixture was stirred at room temperature for 5 minutes. The solvent in the reaction solution was distilled off under reduced pressure to obtain the captioned compound (333 mg).

Provenance & Evidence