Dichloromethane → HCID 86677402, compound

Participants

Reaction Steps

To a mixture of 4-pyridinecarboxylic acid 2-(3-{(R)-(4-{amino[benzoylimino]methyl}phenylamino)-[5-(3-methoxy-2,2-dimethylpropionyloxymethoxy)-1-pyrimidin-2-yl-1H-[1,2,4]triazol-3-yl]methyl}-2-fluoro-5-methoxyphenoxy)ethyl ester (Example 4d, 208 mg), dichloromethane (3 mL), and TBME (6 mL), 0.4 M hydrogen chloride-ethyl acetate solution (0.62 mL) was added dropwise at room temperature. TBME (6 mL) was added to the resulting mixture, and after stirring the resulting mixture for 10 minutes, the mixture was sonicated for 2 minutes. The precipitates were recovered by filtration, washed twice with TBME (5 mL), and dried under reduced pressure. The captioned compound (192 mg) was obtained.

Provenance & Evidence