Dichloromethane → HCID 86677403, compound

Participants

Reaction Steps

To a mixture of 4-pyridinecarboxylic acid 2-(3-{(R)-(4-{amino[benzoylimino]methyl}phenylamino)-[5-(3-methoxy-2,2-dimethylpropionyloxymethoxy)-1-pyrimidin-2-yl-1H-[1,2,4]triazol-3-yl]methyl}-2-fluoro-5-methoxyphenoxy)ethyl ester (219 mg), dichloromethane (3 mL), and TBME (6 mL), a mixture of methanesulfonic acid (0.0171 mL) and dichloromethane (1 mL) was added dropwise at room temperature. TBME (6 mL) was added to the resulting mixture, and after stirring the resulting mixture for 10 minutes, the mixture was sonicated for 2 minutes. The precipitates were recovered by filtration, washed twice with TBME (5 mL), and dried under reduced pressure. The captioned compound (206 mg) was obtained.

Provenance & Evidence