Toluene → 3-methoxy-2,2-dimethylpropionic acid 5-[(R)-[3-(2-acetoxyethoxy)-2-fluoro-5-methoxyphenyl]-(4-{amino[2-methylallyloxycarbonylimino]methyl}phenylamino)methyl]-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxymethyl ester hydrochloride

Participants

Reaction Steps

To a mixture of 3-methoxy-2,2-dimethylpropionic acid 5-[(R)-[3-(2-acetoxyethoxy)-2-fluoro-5-methoxyphenyl]-(4-{amino[2-methylallyloxycarbonylimino]methyl}phenylamino)methyl]-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxymethyl ester (Example 6f, 20 mg) and toluene (4 mL), under stirring at room temperature, a dilution (0.2 mL) prepared by adding 4 M hydrogen chloride-ethyl acetate solution (0.32 mL) to ethyl acetate (10 mL) was added dropwise. The solvent in the mixture was distilled off under reduced pressure to obtain the captioned compound (20 mg).

Provenance & Evidence