Dimethyl Sulfoxide → [1-amino(4-{[(R)-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl](5-oxo-1-pyrimidin-2-yl-4,5-dihydro-1H-[1,2,4]-triazol-3-yl)methyl]amino}phenyl)methylene]carbamic acid 2-methylallyl ester

Participants

Reaction Conditions

Reaction Steps

To a mixture of 4-{[(R)-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl](5-oxo-1-pyrimidin-2-yl-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl]amino}benzamidine (R)-methoxyphenylacetate (0.5 g, 0.755 mmol), potassium carbonate (104 mg, 0.755 mmol), and dimethyl sulfoxide (1.5 mL), carbonic acid 2-methylallyl ester phenyl ester [CAS No. 138621-73-5] (145 mg, 0.755 mmol) was added, and the resulting mixture was stirred at 60° C. for 2 hours and 30 minutes. After cooling the mixture, the reaction solution was added to a mixture of ethyl acetate (5 mL) and water (15 mL), and an aqueous acetic acid solution (prepared from acetic acid (0.1 mL) and water (5 mL)) was added dropwise to the resulting mixture with stirring. The precipitated solid was filtered and sequentially washed with ethyl acetate (10 mL) and water (10 mL). The solid obtained was dried under air flow to obtain the captioned compound (361 mg) as a yellow solid.

Provenance & Evidence