反应详情

At room temperature, 3-methoxy-2,2-dimethylpropionic acid 5-[(R)-[3-(2-acetoxyethoxy)-2-fluoro-5-methoxyphenyl]-(4-{amino[2-methylallyloxycarbonylimino]methyl}phenylamino)methyl]-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxymethyl ester (1.0 g, 1.28 mmol) was dissolved in acetone (80 mL), and a solution of ethanesulfonic acid (127 mg, 1.15 mmol) in acetone (20 mL) was added dropwise thereto. To the resulting mixture, a seed crystal of the captioned compound was added, and the resulting mixture was stirred overnight at room temperature. The precipitated solid was filtered, washed with acetone, and then dried to obtain the captioned compound (889 mg) as a white powder.

1. additionTo the resulting mixture, a seed crystal of the captioned compound was added
2. filtrationThe precipitated solid was filtered
3. washwashed with acetone
4. customdried