反应详情

At room temperature, 3-methoxy-2,2-dimethylpropionic acid 5-[(R)-[3-(2-acetoxyethoxy)-2-fluoro-5-methoxyphenyl]-(4-{amino[2-methylallyloxycarbonylimino]methyl}phenylamino)methyl]-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxymethyl ester (1.0 g, 1.28 mmol) was dissolved in ethyl acetate (100 mL), a solution of 1-propanesulfonic acid [CAS No. 5284-66-2] (151 mg, 1.22 mmol) in ethyl acetate (5 mL) was added dropwise thereto. To the resulting mixture, a seed crystal of the captioned compound was added, and the resulting mixture was stirred overnight at room temperature. The precipitated solid was filtered, sequentially washed with ethyl acetate and tert-butyl methyl ether, and then dried to obtain the captioned compound (950 mg) as a white powder.

1. additionTo the resulting mixture, a seed crystal of the captioned compound was added
2. filtrationThe precipitated solid was filtered
3. washsequentially washed with ethyl acetate and tert-butyl methyl ether
4. customdried