Dimethylformamide dimethyl acetal → HCID 59436265, Verbindung

HRID 2089758Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2089758
[O:1]=[C:2]([CH2:20][CH3:21])[C:3](=[N:8][NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([C:16]([F:19])([F:18])[F:17])[CH:11]=1)[C:4]([O:6][CH3:7])=[O:5].[CH3:22]OC(OC)N(C)C>>[CH3:21][C:20]1[C:2](=[O:1])[C:3]([C:4]([O:6][CH3:7])=[O:5])=[N:8][N:9]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([C:16]([F:17])([F:18])[F:19])[CH:11]=2)[CH:22]=1

Komponenten

3

Edukt 2

HCID 78373Dimethylformamide dimethyl acetalHCID 178459327HCID 178459327, Verbindung

Produkt 1

HCID 59436265HCID 59436265, VerbindungAusbeute 87 %

Versuchsvorschrift

A solution of methyl 3-oxo-2-{[3-(trifluoromethyl)phenyl]hydrazono}pentanoate (4.00 g, 13.2 mmol) in N,N-dimethylformamide dimethylacetal (33 mL) was heated at reflux for 2.5 hours. After that time, the reaction was cooled to room temperature and the resulting solid was collected by filtration and washed with a small amount of hexanes to give methyl 5-methyl-4-oxo-1-[3-(trifluoromethyl)phenyl]-1,4-dihydropyridazine-3-carboxylate (3.55 g, 87%) as a pale yellow solid.

Aufarbeitung

  1. temperatureat reflux for 2.5 hours
  2. filtrationthe resulting solid was collected by filtration
  3. washwashed with a small amount of hexanes

Quellen und Nachweise

ORD-Eintrag
ord-6f9bb8e846bb4068a37470ae73d68948
Quelldatensatz
uspto-grants-2013_05
Patentnummer
US08435995B2

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