Methyl-2-{[4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)benzoyl]amino}-3-methylbutanoate → 2-{[4-(5-Cyano-7-isopropyl-1,3-benzoxazol-2-yl)benzoyl]amino}-3-methylbutanoic acid
Reaction equation
C[O:2][C:3](=[O:31])[CH:4]([NH:8][C:9](=[O:30])[C:10]1[CH:15]=[CH:14][C:13]([C:16]2[O:17][C:18]3[C:24]([CH:25]([CH3:27])[CH3:26])=[CH:23][C:22]([C:28]#[N:29])=[CH:21][C:19]=3[N:20]=2)=[CH:12][CH:11]=1)[CH:5]([CH3:7])[CH3:6].C(C1C=C(C(C)C)C2OC(C3C=CC(C(O)=O)=CC=3)=NC=2C=1)#N>>[C:28]([C:22]1[CH:23]=[C:24]([CH:25]([CH3:27])[CH3:26])[C:18]2[O:17][C:16]([C:13]3[CH:14]=[CH:15][C:10]([C:9]([NH:8][CH:4]([CH:5]([CH3:6])[CH3:7])[C:3]([OH:31])=[O:2])=[O:30])=[CH:11][CH:12]=3)=[N:20][C:19]=2[CH:21]=1)#[N:29]Participants
3
Procedure
The title compound was prepared from methyl-2-{[4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)benzoyl]amino}-3-methylbutanoate (EXAMPLE 29) using procedure analogous to that described in INTERMEDIATE 2, Step C. Mass spectrum (ESI) 406.20 (M+1). 1H NMR (500 MHz, CDCl3): δ 8.19 (d, J=8.4 Hz, 2H), 7.89 (d, J=8.4 Hz, 2H), 7.79 (d, J=1.4 Hz, 1H), 7.38 (s, 1H), 7.02 (d, J=8.4 Hz, 2H), 4.59 (m, 1H), 3.45 (m, 1H), 2.2 m, 1H), 1.32 (d, J=7.10 Hz, 6H), 0.91 (t, J=6.3 Hz, 6H).
Sources & evidence
- ORD record
- ord-a9ce1d6c0ff04e2389eca36dd3a3f827
- Source dataset
- uspto-grants-2013_05
- Patent number
- US08436028B2
Reaction notes
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