HCID 25152788, compound → HCID 178439223, compound

Participants

Reaction Steps

To a solution of 4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)-N-{[4-(4-fluorophenyl)cyclohex-3-en-1-yl]methyl}benzamide (30 mg, 0.061 mmol, EXAMPLE 41) in methanol (1 ml) and tetrahydrofuran (1 ml) was added 10% palladium on carbon (10 mg, 0.094 mmol). The mixture was flushed with nitrogen, then flushed with hydrogen and stirred for 6 h under a hydrogen balloon, at which point LC/MS analysis showed no starting material. The mixture was added directly to a 1000-micron plate and then eluted with 1:1 ethyl acetate-hexanes to provide the desired products trans-4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)-N-{[4-(4-fluorophenyl)cyclohexyl]methyl}benzamide (11.9 mg, 0.024 mmol, 39.5% yield) and cis-4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)-N-{[4-(4-fluorophenyl)cyclohexyl]methyl}benzamide (14.0 mg, 0.028 mmol, 46.5% yield).

Provenance & Evidence