4-(5-Cyano-7-isopropylbenzo[d]oxazol-2-yl)benzoic acid → HCID 178439227, compound

HRID 2090100Notes

Reaction equation

HRID 2090100 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([CH:21]([CH3:23])[CH3:22])[C:6]2[O:10][C:9]([C:11]3[CH:19]=[CH:18][C:14]([C:15](O)=[O:16])=[CH:13][CH:12]=3)=[N:8][C:7]=2[CH:20]=1)#[N:2].[NH2:24][CH2:25][C@H:26]1[CH2:31][CH2:30][C@H:29]([CH2:32][CH2:33][OH:34])[CH2:28][CH2:27]1>>[C:1]([C:3]1[CH:4]=[C:5]([CH:21]([CH3:23])[CH3:22])[C:6]2[O:10][C:9]([C:11]3[CH:19]=[CH:18][C:14]([C:15]([NH:24][CH2:25][C@H:26]4[CH2:31][CH2:30][C@H:29]([CH2:32][CH2:33][OH:34])[CH2:28][CH2:27]4)=[O:16])=[CH:13][CH:12]=3)=[N:8][C:7]=2[CH:20]=1)#[N:2]

Participants

3

Reactant 2

HCID 573699454-(5-Cyano-7-isopropylbenzo[d]oxazol-2-yl)benzoic acid2×HCID 178511235HCID 178511235, compound2×

Product 1

HCID 178439227HCID 178439227, compound

Procedure

The title compound was prepared from 4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)benzoic acid (INTERMEDIATE 2), and 2-[trans-4-(aminomethyl)cyclohexyl]ethanol (INTERMEDIATE 8) as described in EXAMPLE 1. Mass spectrum (ESI) 446.1 (M+1).

Sources & evidence

ORD record
ord-71b7745caae54d74bb80fa6c98fef9f3
Source dataset
uspto-grants-2013_05
Patent number
US08436028B2

Reaction notes

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