反应详情

温度

25 °C

To a solution of 4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)-N-{[trans-4-(2-hydroxyethyl)cyclohexyl]methyl}benzamide (50 mg, 0.112 mmol) in dichloromethane (2 ml) was added Dess-Martin periodinane (60 mg, 0.141 mmol). The mixture was stirred for 2 h at 25° C., at which point LC/MS analysis showed no starting material. The mixture was purified by flash chromatography on a Biotage Horizon, 25M column, eluting with 1 column volume of 100% dichloromethane followed by a gradient of 0 to 100% ethyl acetate in dichloromethane over 10 column volumes to provide the title compound (48 mg, 0.108 mmol, 96% yield). Mass spectrum (ESI) 444.0 (M+1).

1. customThe mixture was purified by flash chromatography on a Biotage Horizon, 25M column
2. washeluting with 1 column volume of 100% dichloromethane