HCID 59381267, compound → HCID 59381264, compound

HRID 2090148Notes

Reaction equation

HRID 2090148 reaction equation
[N+:1]([C:4]1[CH:45]=[CH:44][C:7]([CH2:8][CH:9]([CH2:34][C:35]2[CH:40]=[CH:39][C:38]([N+:41]([O-])=O)=[CH:37][CH:36]=2)[C:10]([O:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][O:19][C:20](=[O:33])[C:21]2[CH:26]=[CH:25][C:24](/[CH:27]=[CH:28]/[C:29]([O:31][CH3:32])=[O:30])=[CH:23][CH:22]=2)=[O:11])=[CH:6][CH:5]=1)([O-])=O>[Zn]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([CH2:8][CH:9]([CH2:34][C:35]2[CH:40]=[CH:39][C:38]([NH2:41])=[CH:37][CH:36]=2)[C:10]([O:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][O:19][C:20](=[O:33])[C:21]2[CH:26]=[CH:25][C:24](/[CH:27]=[CH:28]/[C:29]([O:31][CH3:32])=[O:30])=[CH:23][CH:22]=2)=[O:11])=[CH:44][CH:45]=1

Participants

3

Reactant 1

HCID 59381267HCID 59381267, compound

Product 1

HCID 59381264HCID 59381264, compoundYield 75.3%

Reagents, catalysts & solvents 1

HCID 23994ZincCatalyst

Procedure

Preparation can be carried out analogously to Example 1 using 2.84 g (4.59 mmol) 6-({4-[(1E)-3-methoxy-3-oxoprop-1-enyl]benzoyl}oxy)hexyl 2-(4-nitrobenzyl)-3-(4-nitrophenyl)propanoate, 7.44 g (27.52 mmol) Ferric chloride hexahydrate and 3.00 g (45.89 mmol) Zinc powder yielded 1.93 g (72%) 6-({4-[(1E)-3-methoxy-3-oxoprop-1-enyl]benzoyl}oxy)hexyl 2-(4-aminobenzyl)-3-(4-aminophenyl)propanoate as yellow powder.

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-b32008d6b34b435e927f5dd3ef63dee5
Source dataset
uspto-grants-2013_05
Patent number
US08436132B2

Reaction notes

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