Water → HCID 59349645, compound

Participants

Reaction Steps

7.20 g (17.21 mmol) of the compound from Example 21A are dissolved in 200 ml of 1,2-dimethoxyethane/water (3:1 v/v), mixed with 34.42 ml (34.42 mmol) of 1 N sodium hydroxide solution and stirred at room temperature overnight. The mixture is then mixed with 100 ml of diethyl ether and 100 ml of water, the organic phase is separated off, and the aqueous phase is adjusted to pH 4-5 with 1N hydrochloric acid. The resulting suspension is stirred for 1 h and the precipitated solid is then removed by filtration. The precipitate is washed with water and a little diethyl ether. Drying in vacuo at 40° C. results in 3.57 g (57% of theory) of the title compound.

Provenance & Evidence