Nitric Acid → HCID 178526762, compound

Participants

Reaction Conditions

Reaction Steps

4-Hydroxyquinoline (22.2 g) and propionic acid (200 mL) were combined and heated to 125° C. Nitric acid (21.5 mL) was added dropwise over 1.5 h. The reaction mixture was stirred at reflux temperature for a further 15 min and cooled to rt. The mixture was diluted with ethanol and the solid was collected by vacuum filtration. The solid was washed with ethanol, water then ethanol. The residue was refluxed in ethanol and the hot mixture was filtered and dried to give the subtitle compound. Yield: 22 g

Provenance & Evidence