Valeryl chloride → HCID 22344433, compound

Participants

Reaction Steps

The product from step (iii) (1.23 g) was dissolved in NMP (25 mL) and valeryl chloride (0.46 mL) was added dropwise. The reaction mixture was stirred for 1.5 h at rt, heated to 50° C. for 24 h then heated to 80° C. for 2 days. The solvent was evaporated and the reaction mixture poured into DCM. The solid precipitate was filtered off and the filtrate was purified on silica eluting with 10% MeOH in DCM to give subtitle compound (0.9 g).

Provenance & Evidence