4-Toluenesulfonyl chloride → HCID 10092233, compound

Participants

Reaction Steps

p-Toluenesulphonyl chloride (0.43 g) was added portionwise to a vigourously stirred mixture of the product from step (v) (0.9 g) in DCM (25 mL) and ammonium hydroxide solution (35%, 2.5 mL) at 0° C. The mixture was allowed to warm to rt over 2 h then partitioned between water/DCM, washed with saturated sodium bicarbonate solution, dried, filtered and the solvent evaporated. The solid product was triturated with diethylether to give the subtitle compound (0.6 g).

Provenance & Evidence