HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 1-(3-aminopropyl)-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | HCID 10092233 | HCID 10092233 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-(3-aminopropyl)-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine | HCID 22344413 | — |
Reaction Steps
The product from step (vi) (0.6 g) was dissolved in DCM (5 mL) and TFA (5 mL) was added. The reaction mixture was stirred for 20 min, the solvents were evaporated and the product purified via SCX resin, eluting with ammonia in MeOH solution (3.5%). Yield 380 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08436178B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-d677b397114d4a03b6428887b186e105 |
| Source note | uspto-grants-2013_05 |