反应详情

A mixture of the product from step (v) (0.96 g) and thionyl chloride (10 mL) in DCM (20 mL) was heated under reflux for 6 h then evaporated under reduced pressure. The residue was dissolved in acetonitrile (20 mL) then N,N-dimethylethylenediamine (10 mL) added and the mixture heated under reflux for 24 h. The solvent was removed under reduced pressure and the residue purified by RPHPLC, yield 0.512 g.

1. temperaturewas heated
2. temperatureunder reflux for 6 h
3. customthen evaporated under reduced pressure
4. dissolutionThe residue was dissolved in acetonitrile (20 mL)
5. additionN,N-dimethylethylenediamine (10 mL) added
6. temperaturethe mixture heated
7. temperatureunder reflux for 24 h
8. customThe solvent was removed under reduced pressure
9. customthe residue purified by RPHPLC, yield 0.512 g