HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2090243Generated: October 30, 2026
Methoxyacetic Acid → HCID 22479002, compound
https://huagongshe.com/reaction/2090243
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methoxyacetic Acid | HCID 12251 | — |
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | HCID 66958404 | HCID 66958404 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 22479002 | HCID 22479002 | — |
Reaction Steps
The product from example 1 step (iii) (790 mg) was dissolved in NMP (5 mL), then EDCI (1.44 g), HOBt (1 g), methoxyacetic acid (0.71 mL) and Et3N (1 mL) were added. The mixture was stirred at 40° C. for 15 h then heated at 60° C. for 5 h. After cooling to rt, the crude mixture was dissolved in diethyl ether, washed with brine, dried and evaporated under reduced pressure, which afforded 600 mg of the subtitle product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08436178B2 |
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| Source dataset | uspto-grants-2013_05 |
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| ORD ID | ord-e1577b1ade724ea18ba1e7ebdf63d5df |
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| Source note | uspto-grants-2013_05 |
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