Chloroacetyl chloride → HCID 68432292, compound

HRID 2090245Notes

Reaction equation

HRID 2090245 reaction equation
[Cl:1][CH2:2][C:3](Cl)=[O:4].[NH2:6][C:7]1[C:16]2[N:17]=[C:18]([CH2:36][O:37][CH2:38][CH3:39])[N:19]([CH2:20][CH2:21][CH2:22][NH:23][CH2:24][C:25]3[CH:26]=[C:27]([CH2:31][C:32]([O:34][CH3:35])=[O:33])[CH:28]=[CH:29][CH:30]=3)[C:15]=2[C:14]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[N:8]=1>CC#N>[NH2:6][C:7]1[C:16]2[N:17]=[C:18]([CH2:36][O:37][CH2:38][CH3:39])[N:19]([CH2:20][CH2:21][CH2:22][N:23]([CH2:24][C:25]3[CH:26]=[C:27]([CH2:31][C:32]([O:34][CH3:35])=[O:33])[CH:28]=[CH:29][CH:30]=3)[C:3](=[O:4])[CH2:2][Cl:1])[C:15]=2[C:14]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[N:8]=1

Participants

4

Reactant 2

HCID 6577Chloroacetyl chlorideHCID 68430759HCID 68430759, compound

Product 1

HCID 68432292HCID 68432292, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Chloroacetyl chloride (0.059 mL) was added to the product of step (v) (25 mg) in MeCN (2 mL) at rt under nitrogen. The resulting solution was stirred at rt for 2 h, then concentrated in vacuo and azeotroped with toluene, yield 30 mg.

Workup

  1. concentrationconcentrated in vacuo
  2. customazeotroped with toluene, yield 30 mg

Sources & evidence

ORD record
ord-5e6b2356fab54371bb3ddfddb3bc2933
Source dataset
uspto-grants-2013_05
Patent number
US08436178B2

Reaction notes

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