Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Methyl 2-(3-(((3-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl)(3-chloropropyl)amino)methyl)phenyl)acetate | HCID 68430884 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 59563517 | HCID 59563517 | — |
Reaction Steps
A solution of dimethylamine in THF (2M, 6 mL) was added to a mixture of the product from step (ix) (1.17 mmol) and sodium iodide (250 mg) in DMF (5 mL) at rt. The mixture was heated at 55° C. in a sealed vessel for 24 h, cooled, filtered and the filtrate purifed by RPHPLC. The fractions containing the desired compound were evaporated to dryness and the residue triturated with ether/isohexane, 270 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08436178B2 |
|---|
| Source dataset | uspto-grants-2013_05 |
|---|
| ORD ID | ord-fe3fa2379f044658bc5d5fce914054f3 |
|---|
| Source note | uspto-grants-2013_05 |
|---|
