Morpholine → HCID 59563522, compound

HRID 2090258Notes

Reaction equation

HRID 2090258 reaction equation
[NH2:1][C:2]1[C:11]2[N:12]=[C:13]([CH2:35][CH2:36][CH2:37][CH3:38])[N:14]([CH2:15][CH2:16][CH2:17][N:18]([CH2:23][C:24]3[CH:25]=[C:26]([CH2:30][C:31]([O:33][CH3:34])=[O:32])[CH:27]=[CH:28][CH:29]=3)[CH2:19][CH2:20][CH2:21]Cl)[C:10]=2[C:9]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[N:3]=1.[NH:39]1[CH2:44][CH2:43][O:42][CH2:41][CH2:40]1>>[NH2:1][C:2]1[C:11]2[N:12]=[C:13]([CH2:35][CH2:36][CH2:37][CH3:38])[N:14]([CH2:15][CH2:16][CH2:17][N:18]([CH2:23][C:24]3[CH:25]=[C:26]([CH2:30][C:31]([O:33][CH3:34])=[O:32])[CH:27]=[CH:28][CH:29]=3)[CH2:19][CH2:20][CH2:21][N:39]3[CH2:44][CH2:43][O:42][CH2:41][CH2:40]3)[C:10]=2[C:9]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[N:3]=1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 68430884Methyl 2-(3-(((3-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl)(3-chloropropyl)amino)methyl)phenyl)acetate

Product 1

HCID 59563522HCID 59563522, compound

Procedure

The title compound was prepared by the method of example 11 step (x) using the product from example 11 step (ix) (627 mg) and morpholine (1 ml) to give product as a white solid 165 mg.

Sources & evidence

ORD record
ord-e819715e660a45bcbbdb41f2943e8772
Source dataset
uspto-grants-2013_05
Patent number
US08436178B2

Reaction notes

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